Estimates of the prevalence of androgenetic alopecia range from 23 to 87%.

In individuals with a genetic predisposition, androgenic alopecia (AGA) arises through distinct mechanisms; its frequency and severity rise with age, and men and women experience distinct patterns of hair loss. It is more accurate to classify androgenetic alopecia as male-type and female-type because the pathophysiology, clinical characteristics, and medication management may vary. While the frontal hairline is typically maintained, men lose hair in the frontal, vertex, and occasionally temporal regions of their scalps, while women experience hair loss in the frontal and vertex regions.

Growth factors, cytokines, and microRNAs found in exosomes have the ability to alter signalling pathways related to the growth and regeneration of hair follicles. Furthermore, by attaching to particular membrane receptors, starting signalling cascades, and encouraging the growth and differentiation of hair follicles, exosomes produced from stem cells can engage with target cells. Additionally, the integration of exosomal contents into target cells’ cellular machinery is facilitated by the transfer of membrane proteins from exosomes to recipient cells via membrane fusion, which improves hair follicle growth and function.

Exosomes derived from alternative sources, such as bovine colostrum or plants, may be considered to increase production yield while adhering to GMP (Good Manufacturing Practices)

In summary, there has been exciting advances in the field of exosome research over the past decade, despite significant roadblocks in its clinical translation. There are important safety concerns yet to be addressed. Exosomes are currently not approved by the U.S. Food and Drug Administration (FDA) to treat hair disorders. For alopecia patients, off-label exosome treatment has mainly been restricted to topical use under a cosmetic designation, and may be considered as a part of shared decision-making when conventional treatments fail. (data taken from https://onlinelibrary.wiley.com/doi/10.1111/jocd.15869)

At Skinesis Clinique, We suggest sticking with PRP (Platelet-Rich Plasma) or GFC (Growth Factor Concentrate) are beneficial for the patients having Alopecia (hair loss or looking for hair density) where these two therapies have been proven to have excellent results in hair growth – As suggested by the Dermatologist at Vasant Vihar, Delhi (Skinesis Clinique) – Further details or queries, Kindly contact the councillor at the skin clinic.